Pathanamthitta is connected to other places by roadways and railways. The only railway station in Pathanamthitta district is the Thiruvalla railway station. The nearest railway station to Pathanamthitta is the Chengannur railway station in Alappuzha. Many major express trains to several states in India pass through Thiruvalla railway station.
The PWD road length of Pathanamthitta is estimated to be around 1596 kms. The two State Highways namely Thiruvalla-Kumbazha highway (SH 07) and Main Eastern Highway (SH 08) meets at Pathanamthitta. SH 07 pass only through the Pathanamthitta district. SH 08 which is the second longest State Highway connect Punalur in Kollam district with Muvattupuzha in Ernakulam district. Some other state highways through this district are SH 1, SH 5, SH 6, SH 9, SH 10, SH 12, SH 37, SH 44 and SH 67. The National Highway NH 220 passes through Pathanamthitta district.
There are several buses that include KSRTC and private buses also. There are interstate buses that travel to Bangalore, Coimbatore, Chennai and Mumbai. The main Bus Stations in Pathanamthitta district are Adoor, Mallappally, Pathanamthitta, Pandalam and Thiruvalla bus stations.
There is no airport in Pathanamthitta. The nearest airport is the Thiruvananthapuram International Airport at a distance of 113 kms. The Cochin International Airport is at a distance of 142 kms from Pathanamthitta. Plans have been put forward for a new Private Airport in Aranmula by the company Aranmula Aviation Ltd. This proposed International Airport is set to start its domestic operations in the year 2012.